https://www.finsnobio.com/news daily 0.75 2025-09-24 https://www.finsnobio.com/news/finsnobio-nysnobio-parkin-mitophagy-activators monthly 0.5 2025-09-24 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/80ea5455-cb05-410b-99c0-90c007446b61/finsnobio-activation-PINK1-Parkin-pathway.jpg News - FinsnoBio Publishes in Science Advances - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/c46ba76f-b0ba-4419-a249-8b2d972d0e65/finsnobio-activation-mitochondrial-toxins.jpg News - FinsnoBio Publishes in Science Advances - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.finsnobio.com/news/finsnobio-jennifer-johnston-phd-chairs-first-cns-degrader-meeting monthly 0.5 2023-10-20 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1697747855544-H26RC1QXVKMJRASDKIRB/JJ-speaker-6th-annual-TPD-2023.jpg News - Jennifer Johnston, PhD, Chairs First CNS Degrader Meeting on Oct 30th in Boston - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.finsnobio.com/news/finsnobio-accelero-biostructures-partnership-x-ray-crystallography-drug-discovery monthly 0.5 2023-10-19 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1625431773050-QKHHK3945YPKMDT1CFDR/finsnobio-partnership-accelero-biostructures.png News - FinsnoBio and Accelero Biostructures Announce Partnership for X-Ray Crystallography Drug Discovery - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1625430325879-WJBJY0W00SKDOCKA3J4T/accelero-biostructures-fragment-based-drug-discovery-fbdd.jpg News - FinsnoBio and Accelero Biostructures Announce Partnership for X-Ray Crystallography Drug Discovery - Make it stand out Fragment-based drug discovery (FBDD) https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1625430405539-ZRT0NILI3GO375EWN9B6/accelero-biostructures-x-ray-crystallography-solution.jpg News - FinsnoBio and Accelero Biostructures Announce Partnership for X-Ray Crystallography Drug Discovery - Make it stand out X-ray crystallography solution https://www.finsnobio.com/sarah-finley daily 0.75 2021-03-31 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1617232928163-NYJD0QWYEDX51ZII7L9L/nysnobio-sarah-finley.jpg sarah-finley https://www.finsnobio.com/home daily 1.0 2026-01-02 https://www.finsnobio.com/contact daily 0.75 2025-09-24 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/03e7f629-46f1-4b49-8eb8-22c4f83424f2/LOGO-FinsnoBio-Shad.png https://www.finsnobio.com/science daily 0.75 2021-09-23 https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1625537474463-HZESH5HMLB0SQLC1CJ0D/parkin-dependent-mitophagy.png Science - Make it stand out Parkin-Dependent Mitophagy https://images.squarespace-cdn.com/content/v1/60650404189c0252ef9e8ef9/1617232934730-8ULMM7ZDAQL3VPSP1JZE/nysnobio-E3-ligase-enzymes.jpg Science E3 Ligase Enzymes E3 ligase enzymes act to destroy specific proteins at specific times in specific places. Because of this they are the key mediator for directing cellular fate. E3 ligases chemically add a modification to substrates and this modification signals cellular machinery to degrade the substrate. Small molecules that can control the activity of E3 ligases can be used change the cell fate in the course of disease. While not considered “druggable” in a field confined by traditional drug discovery paradigms NysnoBio’s proprietary approach has resulted in discovery of the first small molecule Parkin activators. Our team published the first crystal structure of the Parkin enzyme and this insight provides the foundation for our small molecule drug discovery program. We are committed to leverage our deep understanding of the fundamentals of E3 ligase enzymology into effective therapeutics for patient benefit. 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